Abstract
Extra virgin olive oil (EVOO) is consumed as part of the health promoting Mediterranean diet and contains several phenolic compounds that are responsible for the unique and distinctive flavour of EVOO. The phenolic fraction of EVOO also imparts many beneficial effects on human health. Oleocanthal is an EVOO phenolic that shares a unique perceptual quality with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen and also mimics the anti-inflammatory actions of this drug. Oleocanthal has therefore been deemed a naturally occurring NSAID because of its demonstrated attenuation of cyclooxygenase (COX) activity in a dose dependent manner. New and emerging research has reported that oleocanthal also acts on inflammatory markers associated with neurodegenerative disease, joint degenerative disease, and cancer. This review will give an up-to-date summary of the history of oleocanthal and the current evidence establishing oleocanthal as a potent natural anti-inflammatory agent.
Keywords: Extra virgin olive oil, Mediterranean diet, Oleocanthal, Phenolic compound, Inflammation, Chronic disease, Alzheimer’s disease, Nitric oxide, Osteoarthritis.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:The Anti-Inflammatory and Pharmacological Actions of Oleocanthal, a Phenolic Contained in Extra Virgin Olive Oil
Volume: 10 Issue: 6
Author(s): Lisa Lucas, Sara Cicerale and Russell Keast
Affiliation:
Keywords: Extra virgin olive oil, Mediterranean diet, Oleocanthal, Phenolic compound, Inflammation, Chronic disease, Alzheimer’s disease, Nitric oxide, Osteoarthritis.
Abstract: Extra virgin olive oil (EVOO) is consumed as part of the health promoting Mediterranean diet and contains several phenolic compounds that are responsible for the unique and distinctive flavour of EVOO. The phenolic fraction of EVOO also imparts many beneficial effects on human health. Oleocanthal is an EVOO phenolic that shares a unique perceptual quality with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen and also mimics the anti-inflammatory actions of this drug. Oleocanthal has therefore been deemed a naturally occurring NSAID because of its demonstrated attenuation of cyclooxygenase (COX) activity in a dose dependent manner. New and emerging research has reported that oleocanthal also acts on inflammatory markers associated with neurodegenerative disease, joint degenerative disease, and cancer. This review will give an up-to-date summary of the history of oleocanthal and the current evidence establishing oleocanthal as a potent natural anti-inflammatory agent.
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Cite this article as:
Lucas Lisa, Cicerale Sara and Keast Russell, The Anti-Inflammatory and Pharmacological Actions of Oleocanthal, a Phenolic Contained in Extra Virgin Olive Oil, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (6) . https://dx.doi.org/10.2174/1871523011109060399
DOI https://dx.doi.org/10.2174/1871523011109060399 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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