Abstract
The development of drug delivery systems in experimental therapy usually requires in vitro release models, that should posses specific characteristics including: low cost, simple procedure, high reproducibility and very importantly resemble as strictly as possible the in vivo behaviour. In this respect, the paper describes the effects of the use of different experimental procedures on the drug release profiles from controlled delivery formulations based on nano and micro systems. As examples of micro and nanosystems, microparticles constituted of poly-lactide-co-glycolide (PEM) or gelatine (GEM) and nanostructured lipid carriers (NLC) or cubosomes (CBS) were selected, respectively. All the analysed formulations contained bromocriptine (BC) that represents a poorly water-soluble drug. The influence of the experimental release method and of release media has been investigated using different experimental set-up including direct and reverse dialysis, flow-through cell, USP XXII paddle and Franz cell methods.
Keywords: Drug delivery formulations, Microsystems, Nanosystems, Drug release profiles
Current Analytical Chemistry
Title:Analysis of the Drug Release Profiles from Formulations Based on Micro and Nano Systems
Volume: 9 Issue: 1
Author(s): Elisabetta Esposito, Stefania Mazzitelli, Rita Cortesi, Markus Drechsler, Laura Ravani, Claudio Nastruzzi
Affiliation:
Keywords: Drug delivery formulations, Microsystems, Nanosystems, Drug release profiles
Abstract: The development of drug delivery systems in experimental therapy usually requires in vitro release models, that should posses specific characteristics including: low cost, simple procedure, high reproducibility and very importantly resemble as strictly as possible the in vivo behaviour. In this respect, the paper describes the effects of the use of different experimental procedures on the drug release profiles from controlled delivery formulations based on nano and micro systems. As examples of micro and nanosystems, microparticles constituted of poly-lactide-co-glycolide (PEM) or gelatine (GEM) and nanostructured lipid carriers (NLC) or cubosomes (CBS) were selected, respectively. All the analysed formulations contained bromocriptine (BC) that represents a poorly water-soluble drug. The influence of the experimental release method and of release media has been investigated using different experimental set-up including direct and reverse dialysis, flow-through cell, USP XXII paddle and Franz cell methods.
Export Options
About this article
Cite this article as:
Elisabetta Esposito, Stefania Mazzitelli, Rita Cortesi, Markus Drechsler, Laura Ravani, Claudio Nastruzzi , Analysis of the Drug Release Profiles from Formulations Based on Micro and Nano Systems, Current Analytical Chemistry 2013; 9 (1) . https://dx.doi.org/10.2174/1573411011309010037
DOI https://dx.doi.org/10.2174/1573411011309010037 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Analytical methods for environmental and food analysis
In recent years, the study of the chemical composition of food and the environment depends on analytical methods in order to acquire information about the chemical composition, processing, quality control and contamination of soil, water, air, plants and foods, aspects very important for food safety and environmental quality control. There ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
Bioanalytical and Biosensor Technologies for Target Molecules
Bioanalytical and biosensor technologies constitute the core of detecting and sensing diverse molecules within living organisms, encompassing proteins, DNA, small molecular metabolites, and beyond. These molecules assume pivotal roles in biological processes, rendering their analysis and sensing indispensable for comprehending biological phenomena and unraveling disease mechanisms. In the current landscape ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Waist-to-Hip Ratio (WHR) is Conversely Correlated to LAMP-2 Gene Expression Level: A Predictor for Lysosomal Lipid Entrance System
Current Nutrition & Food Science Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal: Possible New Therapy for Pain Management
Current Neuropharmacology Cholesterol Efflux and Reverse Cholesterol Transport: Experimental Approaches
Current Medicinal Chemistry Innovative formulations for controlled drug delivery to the lungs and the technical and toxicological challenges to overcome<sup>#</sup>
Current Pharmaceutical Design Rapid Translation System (RTS): A Promising Alternative for Recombinant Protein Production
Current Protein & Peptide Science Mitochondrial Thymidine Kinase Inhibitors
Current Topics in Medicinal Chemistry The Quest for Surrogate Markers of Angiogenesis: A Paradigm for Translational Research in Tumor Angiogenesis and Anti- Angiogenesis Trials
Current Molecular Medicine Lenalidomide – Current Understanding of Mechanistic Properties
Anti-Cancer Agents in Medicinal Chemistry Inhibition of Sphingomyelin Hydrolysis: Targeting the Lipid Mediator Ceramide as a Key Regulator of Cellular Fate
Current Medicinal Chemistry Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis
Current Protein & Peptide Science Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease
Current Topics in Medicinal Chemistry Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation
Current Drug Targets Nanoparticle Interaction with Biomolecules: How it Shapes the Nano-Effects on Immunity
Current Bionanotechnology (Discontinued) Confocal Microscopy Evidence of Prion Protein Fragment hPrP[173-195] Internalization in Rat B104 Neuroblastoma Cell Line
Protein & Peptide Letters The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer’s Disease
Current Alzheimer Research Therapeutic Advances in the Treatment of Alzheimer's Disease: Present and Future
Current Drug Therapy Metabotropic Glutamate Receptors as Therapeutic Targets for Cognitive Disorders
Current Topics in Medicinal Chemistry Cystic Fibrosis Gene Therapy: Key Questions and Prospects
Current Pediatric Reviews Behavioral Pharmacology of Cannabinoids with a Focus on Preclinical Models for Studying Reinforcing and Dependence-Producing Properties
Current Drug Abuse Reviews Propofol: Therapeutic Indications and Side-Effects
Current Pharmaceutical Design