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Recent Patents on Biomarkers
ISSN (Print): 2210-3090
ISSN (Online): 2210-3104
VOLUME: 3
ISSUE: 1
DOI: 10.2174/2210309011303010044









Trends in Patents of Enzymatic Biomarkers for Early Detection of Bacteria

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Author(s): Savio Morato de Lacerda Gontijo, Luis F. Morgan, Celia R.M. Lanza, Tamara L. Rodriguez, Claudio R. Martinez, Ruben D. Sinisterra and Maria E. Cortes
Pages 44-56 (13)
Abstract:
Delayed or improper diagnosis of bacterial infection can result in sepsis, serious, and often deadly or inflammatory response. Thus, there is a need for a simple assay that can detect low levels of bacteria, which are faster and sensitive in order to provide data for establish treatment decisions in a clinically relevant time frame. Advances in materials research and molecular biology play an important role in understand and development the best way for bacterial diagnosis kits and methods to reach specific targets from the cellular metabolism such as particular enzymes. Recent changes in the diagnostic methods are using simple techniques especially focus to distinguish enzymatic reactions, dependent on substrate and biochemical allowing the bacteria presence detection by very fast reactions. This review highlights the state-ofart in patents of enzymatic biomarkers for early detection of bacteria based-on nanostructures chromogenic or fluorogenic.
Keywords:
Bacteria, chromogenic, diagnosis, early detection, enzymatic biomarkers, fluorogenic, Nanostructures, nanodevices, Enzyme-substrates, Coumarin derivatives
Affiliation:
Restorative Dentistry, Dentistry Faculty, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, CEP 31270-901 Belo Horizonte, MG, Brazil.