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Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
ISSN (Print): 1872-2148
ISSN (Online): 2212-3334
VOLUME: 7
ISSUE: 1
DOI: 10.2174/1872214811307010001









Cancer Therapy Based on a Mechanism of Action for Controlling the Immune System and the Resulting Patent Portfolio

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Author(s): Visala C. Goswitz and Z. Peter Sawicki
Pages 1-10 (10)
Abstract:
Despite decades of research, current cancer therapies extend survival but often do not actually cure the disease. Immune cell based therapy is described here that can eliminate tumor cells without the toxicity associated with chemotherapy or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft vs. tumor (GVT) effects but accompanied by the undesirable graft vs. host disease (GVHD). The mechanism described here relates to generating the Mirror Effect™ that elicits a host vs. tumor (HVT) effect along with a non-toxic host vs. graft (HVG) response. The HVT effect generated by inducing the Mirror Effect™ in a host is effective in cancer therapy, as well as other diseases. The patent strategy, employed for successful patent prosecution related to the elucidation of the Mirror Effect™, is also discussed.
Keywords:
Allogeneic cells, cancer therapy, cytokines, HVG, HVT, immune cells, Mirror Effect™, IMMUNOTHERAPY, TH1/TH2 RESPONSE, IMMUNE CELLS
Affiliation:
Westman, Champlin and Kelly, P.A. 900 Second Avenue South, Suite 1400; Minneapolis, MN 55402 USA.