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Current Organic Chemistry
ISSN (Print): 1385-2728
ISSN (Online): 1875-5348
VOLUME: 17
ISSUE: 2
DOI: 10.2174/1385272811317020006      Price:  $58









Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling

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Author(s): Camelia Elena Stecoza, Magdalena Majekova, Pavol Majek, Miron Teodor Caproiu and Luminita Marutescu
Pages 113-124 (12)
Abstract:
New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The oximes exhibited anti- A. baumanii activity.

Some of the compounds exhibited good antibiofilm activity against the Gram-negative, non-fermentative bacilli P. aeruginosa and A. baumanii, and their possible target suggested by molecular modeling being the synthesis of the quorum sensing molecules employed by the Gram-negative microorganisms represented by N-acyl-l-homoserine lactones.

Keywords:
Dibenzothiepins, Anti-biofilm activity, Molecular modelling, A. baumanii
Affiliation:
Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava, Slovakia.