Login

Journal Image
Recent Patents on CNS Drug Discovery
ISSN (Print): 1574-8898
ISSN (Online): 2212-3954
VOLUME: 8
ISSUE: 1
DOI: 10.2174/1574889811308010007









Targets of Anti-glucocorticoid Therapy for Stress-related Diseases

img
Author(s): Antonio Martocchia, Manuela Stefanelli, Giulia M Falaschi, Lavinia Toussan, Massimiliano Rocchietti March, Silvia Raja, Gloria Romano and Paolo Falaschi
Pages 79-87 (9)
Abstract:
The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions.

Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed.

Keywords:
Corticosteroid, HPA axis, glucocorticoid receptor, stress.
Affiliation:
S. Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy.