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Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry
ISSN (Print): 2211-3525
ISSN (Online): 2211-3533
VOLUME: 12
ISSUE: 1
DOI: 10.2174/22113525113119990114









Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine

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Author(s): Kamel Alhanout, Carole D. Giorgio, Michel D. Meo and Jean M. Brunel
Pages 75-79 (5)
Abstract:
Squalamine, a natural aminosterol compound isolated from the dogfish shark Squalus acanthias, is reported to possess high antimicrobial activities. Herein, we assessed its in vitro genotoxic properties by using the Ames test and the micronucleus assay. All the experimental results demonstrate that squalamine is a non genotoxic molecule and call for further work to evaluate its potent human therapeutic use as a new class of antinfectious agents.
Keywords:
Ames test, antimicrobial agent, non-genotoxic, squalamine.
Affiliation:
Centre de Recherche en Cancerologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Universite, UM 105; Inserm, U1068, F-13009, Marseille, France.