Abstract
The aim of this work was to investigate the antibacterial activity of clove (Syzygium aromaticum) essential oil against multidrug resistant clinical strains of Klebsiella pneumoniae ESBL+. Materials: The antibacterial activity of the oil was tested against standard strain Klebsiella pneumoniae ATCC 700603 and 60 clinical strains of Klebsiella pneumoniae isolated from patients with infections of the respiratory tract, abdominal cavity, urinary tract, skin and from the hospital environment. Methods: The agar dilution method was used to assess the inhibition of microbial growth at various concentrations of the clove oil. Susceptibility testing to antibiotics was carried out using disc-diffusion. Results: The results of experiments showed that clove essential oil possessed very strong activity against all of the clinical strains of extendedspectrum β-lactamase (ESBL)-producing ESBL+ from Klebsiella pneumoniae. Conclusions: The results of this study suggest the potential use of clove essential oil against K. pneumoniae ESBL+ that is responsible for infections difficult to treat. Essential oils my be an excellent alternative for synthetic preparations and, used in combination with antibiotics, may prevent antibiotic-resistant strain development.
Keywords: Clove essential oil, ESBL+, K. pneumoniae, Minimal Inhibitory Concentration.
Anti-Infective Agents
Title:The Susceptibility of Klebsiella pneumoniae ESBL+ Strains to Clove (Syzygium aromaticum) Essential Oil
Volume: 11 Issue: 2
Author(s): Monika Sienkiewicz, Danuta Kalemba and Malgorzata Wasiela
Affiliation:
Keywords: Clove essential oil, ESBL+, K. pneumoniae, Minimal Inhibitory Concentration.
Abstract: The aim of this work was to investigate the antibacterial activity of clove (Syzygium aromaticum) essential oil against multidrug resistant clinical strains of Klebsiella pneumoniae ESBL+. Materials: The antibacterial activity of the oil was tested against standard strain Klebsiella pneumoniae ATCC 700603 and 60 clinical strains of Klebsiella pneumoniae isolated from patients with infections of the respiratory tract, abdominal cavity, urinary tract, skin and from the hospital environment. Methods: The agar dilution method was used to assess the inhibition of microbial growth at various concentrations of the clove oil. Susceptibility testing to antibiotics was carried out using disc-diffusion. Results: The results of experiments showed that clove essential oil possessed very strong activity against all of the clinical strains of extendedspectrum β-lactamase (ESBL)-producing ESBL+ from Klebsiella pneumoniae. Conclusions: The results of this study suggest the potential use of clove essential oil against K. pneumoniae ESBL+ that is responsible for infections difficult to treat. Essential oils my be an excellent alternative for synthetic preparations and, used in combination with antibiotics, may prevent antibiotic-resistant strain development.
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Cite this article as:
Sienkiewicz Monika, Kalemba Danuta and Wasiela Malgorzata, The Susceptibility of Klebsiella pneumoniae ESBL+ Strains to Clove (Syzygium aromaticum) Essential Oil, Anti-Infective Agents 2013; 11 (2) . https://dx.doi.org/10.2174/2211352511311020010
DOI https://dx.doi.org/10.2174/2211352511311020010 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
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