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Current Bioactive Compounds
ISSN (Print): 1573-4072
ISSN (Online): 1875-6646
VOLUME: 9
ISSUE: 2
DOI: 10.2174/15734072113099990011      Price:  $58









Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides

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Author(s): Fawzy. A. Attaby, Ahmed H. El-Ghandour, Abdelwahed R. Sayed, Ashraf A. El Bassuony and Ahmed A. M. El-Reedy
Pages 167-181 (15)
Abstract:
A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3- b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and high to excellent yields, simple experimental and work-up procedure. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR, mass spectra and elemental analyses.
Keywords:
Thienopyridines, pyridinethiones pyridothienopyrimidinones, thienopyridineoxadiazoles, pyrazolothienopyridinone.
Affiliation:
Cairo University, Faculty of Science, Chemistry Department.