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Current Drug Delivery
ISSN (Print): 1567-2018
ISSN (Online): 1875-5704
DOI: 10.2174/15672018113109990044      Price:  $58

Solid Dispersion in Pharmaceutical Drug Development: From Basics to Clinical Applications

Author(s): Punit Bhatnagar, Vinod Dhote, Suresh Chandra Mahajan, Pradyumna Kumar Mishra and Dinesh Kumar Mishra
Pages 155-171 (17)
The solubility of drugs is one of the most challenging aspects in developing formulations for novel drug discovery. Myriad of approaches have been developed and tested to overcome the associated intricacies involved with poor water soluble drugs. Out of the available technologies, solid dispersion (SD) method that significantly enhances the solubility and bioavailability by reducing particle size to a micro-molecular level is often viewed as a promising strategy. Although conceptual basis of manufacturing processes involved in SD method have been reported, formulation characteristics addressing solubility issues remains yet elusive. The current review portray the historical milestones, classification, probable mechanisms for enhancement of solubility, manufacturing processes at commercial level along with pioneer breakthroughs in field that enunciates the versatile pharmaceutical application for categories including anti-cancer and anti-retroviral drugs. Besides, our article also highlights the translational implications of drug development by SD method hitherto unreported.
Drug development, Molecular targeting, Nanomedicine, Pharmaceutical biotechnology, Solid dispersion.
Department of Pharmaceutics, College of Pharmacy, IPS Academy, Indore (M.P.) India.