Login

Journal Image
Current Organic Synthesis
ISSN (Print): 1570-1794
ISSN (Online): 1875-6271
VOLUME: 11
ISSUE: 3
DOI: 10.2174/15701794113109990061      Price:  $58









Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

img
Author(s): Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo and Donatella Granchi
Pages 461-465 (5)
Abstract:
A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.
Graphical Abstract:
Keywords:
Apolipoprotein E, bisphosphonates, gem-phosphonate-phosphate rearrangement, isoxazolidines, ring opening, transition-metal carbonyls.
Affiliation:
Dipartimento di Chimica e Tecnologie Chimiche, Via P. Bucci, cubo 12C, Universita della Calabria, Rende (Italy).