Development and Anti-microbial Potential of Topical Formulations Containing Cocos nucifera Linn.
Ravi Sheshala, Ling Teck Ying, Ling Shiau Hui, Ankur Barua and Kamal Dua
Pages 253-264 (12)
In order to achieve better treatment for local wounds and bacterial infections, topical formulations containing
Cocos nucifera Linn. were developed. These formulations were evaluated for their physicochemical properties and antimicrobial
efficacy against various strains of microorganisms. Semisolid formulations containing 5% w/w of Cocos nucifera
Linn. were prepared by employing different dermatological bases and were evaluated for their physical appearance, pH,
rheological properties, FTIR-spectroscopic analysis, thermodynamic stability and stability studies. The antimicrobial activity
of each prepared formulation was determined using disk-diffusion method against various strains of microorganisms.
All the prepared formulations were found to be stable and exhibited suitable physicochemical characteristics including
pH, viscosity and spreadability which are necessary for an ideal topical preparation, in addition to strong antimicrobial
activity. Carbopol gel base was found to be the most suitable dermatological base for Cocos nucifera Linn. in comparsion
to other bases. Cocos nucifera Linn. formulations showed great potential for wounds and local bacterial infections.
Moreover, carbopol gel base with its aesthetic appeal was found to be a suitable dermatological base for Cocos nucifera
Linn. semisolid formulation as it had demonstrated significant physicochemical properties and greater diffusion when assessed
using disk- diffusion method.
Antimicrobial, carbopol, Cocos nucifera Linn., disk- diffusion method, physicochemical properties, topical.
Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.