Generic placeholder image

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Development and Anti-microbial Potential of Topical Formulations Containing Cocos nucifera Linn.

Author(s): Ravi Sheshala, Ling Teck Ying, Ling Shiau Hui, Ankur Barua and Kamal Dua

Volume 12, Issue 3, 2013

Page: [253 - 264] Pages: 12

DOI: 10.2174/18715230113129990012

Price: $65

Abstract

In order to achieve better treatment for local wounds and bacterial infections, topical formulations containing Cocos nucifera Linn. were developed. These formulations were evaluated for their physicochemical properties and antimicrobial efficacy against various strains of microorganisms. Semisolid formulations containing 5% w/w of Cocos nucifera Linn. were prepared by employing different dermatological bases and were evaluated for their physical appearance, pH, rheological properties, FTIR-spectroscopic analysis, thermodynamic stability and stability studies. The antimicrobial activity of each prepared formulation was determined using disk-diffusion method against various strains of microorganisms. All the prepared formulations were found to be stable and exhibited suitable physicochemical characteristics including pH, viscosity and spreadability which are necessary for an ideal topical preparation, in addition to strong antimicrobial activity. Carbopol gel base was found to be the most suitable dermatological base for Cocos nucifera Linn. in comparsion to other bases. Cocos nucifera Linn. formulations showed great potential for wounds and local bacterial infections. Moreover, carbopol gel base with its aesthetic appeal was found to be a suitable dermatological base for Cocos nucifera Linn. semisolid formulation as it had demonstrated significant physicochemical properties and greater diffusion when assessed using disk- diffusion method.

Keywords: Antimicrobial, carbopol, Cocos nucifera Linn., disk- diffusion method, physicochemical properties, topical.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy