Login

Journal Image
Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 11
ISSUE: 2
DOI: 10.2174/15701808113109990049      Price:  $58









Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity

img
Author(s): Jingwei Zhang, Xusheng Shao, Zhong Li and Xiaoyong Xu
Pages 150-155 (6)
Abstract:
Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively. The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).
Keywords:
Divalent, Neonicotinoid, Activity, Insecticide.
Affiliation:
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Xiaoyong Xu.