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Current Radiopharmaceuticals
ISSN (Print): 1874-4710
ISSN (Online): 1874-4729
DOI: 10.2174/18744710113069990020      Price:  $58

New Issues for Copper-64: from Precursor to Innovative Pet Tracers in Clinical Oncology

Author(s): Laura Evangelista, Mansi Luigi and Giuseppe Lucio Cascini
Pages 117-123 (7)
The role of copper in the metabolism of human cancer cells has been largely investigated in the last 20 years and a strong relationship between copper levels and cancer progression has been demonstrated. Moreover copper is involved in tumor angiogenesis as well as in non-neoplastic conditions like neurodegenerative diseases. The main mechanism of action is related to a cellular transporter (CTR1) that plays a pivotal role in preserving the intra-cellular homeostasis, allowing at the same time the anti- tumor activity of platinum based therapies. Copper-64, emitting positrons and ß - radiations, is suitable for the labeling of a large number of molecules that could be used for radionuclide imaging, being also usable in radionuclide therapy. Nevertheless few data are at present available on radiotracers labeled with radiocopper and in particular on the use of 64Cu-Cl2 in cancer patients. In this paper we analyze the potential applications for Copper-64 as PET agent in the clinical oncological scenario.
Copper-64, molecular imaging, chemo-resistance, breast cancer, prostate cancer.
Medicina Nucleare, Seconda Università di Napoli, Piazza Miraglia, 80138 Napoli, Italy.