Abstract
The present paper reports an easy preparation of imines of N-methyl-1H-indole-3-carboxaldehyde by its condensation with alkyl and aromatic amines in ethanol without using any catalyst or dehydrating agent. The compounds have been screened for their antibacterial, antifungal, crown gall tumor inhibitory, and cytotoxic activities. As a major finding some of the compounds exhibited potential biological activity. The imine containing a 4-chlorophenyl group exhibits potential antitumor activity and brine shrimp lethality against crown gall tumor and brine shrimps, respectively. Furthermore, this imine containing a 4-chlorophenyl group also exhibits significant antifungal activity against Candida albicans fungal strains. The compound containing N-diphenylmethyl group has been observed most active against the Gram-positive bacteria.
Keywords: Antibacterial, antifungal, antitumor, cytotoxicity, Imines, N-Methyl-1H-indole.
Medicinal Chemistry
Title:Antimicrobial, Crown Gall Tumor Inhibitory and Cytotoxicity Assays of N-[(1-methyl-1H-indole-3-yl)methylene]amines Synthesized by an Improved Protocol
Volume: 10 Issue: 4
Author(s): Girija S. Singh, Yasser M.S.A. Al-kahraman, Disah Mpadi and Masoom Yasinzai
Affiliation:
Keywords: Antibacterial, antifungal, antitumor, cytotoxicity, Imines, N-Methyl-1H-indole.
Abstract: The present paper reports an easy preparation of imines of N-methyl-1H-indole-3-carboxaldehyde by its condensation with alkyl and aromatic amines in ethanol without using any catalyst or dehydrating agent. The compounds have been screened for their antibacterial, antifungal, crown gall tumor inhibitory, and cytotoxic activities. As a major finding some of the compounds exhibited potential biological activity. The imine containing a 4-chlorophenyl group exhibits potential antitumor activity and brine shrimp lethality against crown gall tumor and brine shrimps, respectively. Furthermore, this imine containing a 4-chlorophenyl group also exhibits significant antifungal activity against Candida albicans fungal strains. The compound containing N-diphenylmethyl group has been observed most active against the Gram-positive bacteria.
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Cite this article as:
Singh S. Girija, Al-kahraman M.S.A. Yasser, Mpadi Disah and Yasinzai Masoom, Antimicrobial, Crown Gall Tumor Inhibitory and Cytotoxicity Assays of N-[(1-methyl-1H-indole-3-yl)methylene]amines Synthesized by an Improved Protocol, Medicinal Chemistry 2014; 10 (4) . https://dx.doi.org/10.2174/15734064113099990035
DOI https://dx.doi.org/10.2174/15734064113099990035 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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