Abstract
A series of new analogs fluorine containing heterocyclic system viz. 4-benzofuran-2-yl-6-phenyl-pyrimidin-2- ylamine has been synthesized and evaluated for in vitro antibacterial and antifungal activities. Microwave assisted Claisen-Schmidt condensation of 2-acetylbenzofuran (3) with fluorinated benzaldehydes (4) afforded corresponding fluorinated chalcones (5a-g). The cyclocondensation of chalcones with guanidine hydrochloride in alkaline media under microwave resulted in the formation of corresponding fluorine containing 4-benzofuran-2-yl-6-phenyl-pyrimidin-2- ylamines (6a-g). All the synthesized compounds have been characterized on the basis of analytical and spectral data and were screened for their antibacterial and antifungal activities. Some of the synthesized compounds showed good antimicrobial activities against bacteria and fungi.
Keywords: Claisen-Schmidt condensation, microwave assisted synthesis, benzofuran, pyrimidine, antimicrobial.
Medicinal Chemistry
Title:Microwave Assisted Synthesis and in vitro Antimicrobial Activities of Fluorine Containing 4-Benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamines
Volume: 10 Issue: 4
Author(s): Tejpal Singh Chundawat, Nutan Sharma and Sunita Bhagat
Affiliation:
Keywords: Claisen-Schmidt condensation, microwave assisted synthesis, benzofuran, pyrimidine, antimicrobial.
Abstract: A series of new analogs fluorine containing heterocyclic system viz. 4-benzofuran-2-yl-6-phenyl-pyrimidin-2- ylamine has been synthesized and evaluated for in vitro antibacterial and antifungal activities. Microwave assisted Claisen-Schmidt condensation of 2-acetylbenzofuran (3) with fluorinated benzaldehydes (4) afforded corresponding fluorinated chalcones (5a-g). The cyclocondensation of chalcones with guanidine hydrochloride in alkaline media under microwave resulted in the formation of corresponding fluorine containing 4-benzofuran-2-yl-6-phenyl-pyrimidin-2- ylamines (6a-g). All the synthesized compounds have been characterized on the basis of analytical and spectral data and were screened for their antibacterial and antifungal activities. Some of the synthesized compounds showed good antimicrobial activities against bacteria and fungi.
Export Options
About this article
Cite this article as:
Chundawat Singh Tejpal, Sharma Nutan and Bhagat Sunita, Microwave Assisted Synthesis and in vitro Antimicrobial Activities of Fluorine Containing 4-Benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamines, Medicinal Chemistry 2014; 10 (4) . https://dx.doi.org/10.2174/15734064113099990036
DOI https://dx.doi.org/10.2174/15734064113099990036 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
Call for Papers in Thematic Issues
Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Clinical Impact of Quantitative Cell-free DNA, KRAS, and BRAF Mutations on Response to Anti-EGFR Treatment in Patients with Metastatic Colorectal Cancer
Current Pharmaceutical Design Recent Advancement in Predicting Subcellular Localization of Mycobacterial Protein with Machine Learning Methods
Medicinal Chemistry Biological Activities of Yarrow Species (Achillea spp.)
Current Pharmaceutical Design Self-assembly of DNA-based Nanomaterials and Potential Application in Drug Delivery
Current Topics in Medicinal Chemistry Fluorescent Substrates Useful as High Throughput Screening Tools for ADAM9
Combinatorial Chemistry & High Throughput Screening Bis (Isothiocyanatomethyl) Benzene, A Plant Derived Anti-Neoplastic Compound: Purified from Moringa Oleifera Leaf Extract
Anti-Cancer Agents in Medicinal Chemistry Synthesis of New N1Arylpiperazine Substituted Xanthine Derivatives and Evaluation of their Antioxidant and Cytotoxic Effects
Anti-Cancer Agents in Medicinal Chemistry Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
Current Drug Targets Polyelectrolyte-graphene Nanocomposites for Biosensing Applications
Current Organic Chemistry Matrix Gelatinases in Atherosclerosis and Diabetic Nephropathy: Progress and Challenges
Current Vascular Pharmacology MD-LBP: An Efficient Computational Model for Protein Subcellular Localization from HeLa Cell Lines Using SVM
Current Bioinformatics Possibility of Non-Immunosuppressive Immunophilin Ligands as Potential Therapeutic Agents for Parkinsons Disease
Current Pharmaceutical Design Unconventional Interaction Forces in Protein and Protein-ligand Systems and their Impacts to Drug Design
Current Topics in Medicinal Chemistry HDL Genetic Defects
Current Pharmaceutical Design Reduction of Doxorubicin-Induced Cardiotoxicity Using Nanocarriers: A Review
Current Drug Metabolism Degradation of Ofloxacin in Aqueous Phase Using TiO2/ZnO
Nanoscience & Nanotechnology-Asia The Role of Proteomics in Osteoarthritis Pathogenesis Research
Current Drug Targets In Vitro Inhibition Effect and Molecular Docking Study of Curcumin, Resveratrol, and Quercetin on Human Erythrocyte Glutathione Transferase
Current Enzyme Inhibition Comparative Mass Spectrometry & Nuclear Magnetic Resonance Metabolomic Approaches for Nutraceuticals Quality Control Analysis: A Brief Review
Recent Patents on Biotechnology A Review: Stripping Voltammetric Methods as a High Sensitive Strategy for Trace Analysis of Ions, Pharmaceutical and Food Samples
Current Analytical Chemistry