Sugar Furanoses as Useful Handles for Molecular Diversity
Ana M. Gomez, Clara Uriel, Fernando Lobo and Jose Cristobal Lopez
Pages 342-360 (19)
Carbohydrates have been recognized as privileged structures for the regio- and stereo-controlled appendage of pharmacophores
to generate new derivatives with potential application in drug discovery processes. Even though most of the carbohydrate templates
have been generated from pyranoses, other sugar derivatives have also been employed in the assembly of such structures. In this review,
attention has been directed to the use of sugar-furanose platforms, and an account of the recent developments in the generation of
furanose-based templates aiming at the generation of molecular diversity, including those from our research group, is presented.
Carbohydrates, furanoses, molecular diversity, regioselectivity, stereocontrol, spatial arrangement, templates.
Instituto de Quimica Organica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.