Abstract
There is a vast literature dealing with various aspects of the circadian clock. This review provides examples of the multifaceted nature, of namely redox, oxidative stress, melatonin, antioxidants, nitric oxide, hypoxia, anesthetics, cortisol and cocaine. The redox and oxidative stress features reflect the involvement of electron transfer and radical species, which can exert either beneficial or deleterious effects. The harmful aspects can be countered by antioxidants. Melatonin is a brain hormone that is known to play a widespread role in the biochemistry of the circadian clock. Nitric oxide is widespread in the human body and plays a variety of roles. Hypoxia has been broadly discussed in relation to circadian rhythm, e.g., in high altitude flight. The anesthetic topic completes the list.
Keywords: Antioxidants, circadian rhythms, cortisol, cocaine, hypoxia, melatonin, nitric oxide, oxidative stress, redox states.
Current Chemical Biology
Title:Multifaceted Approach to Circadian Rhythm: Redox, Oxidative Stress, Melatonin, Antioxidants, Nitric Oxide, Hypoxia, Anesthetics, Cortisol and Cocaine
Volume: 7 Issue: 3
Author(s): Peter Kovacic and Ratnasamy Somanathan
Affiliation:
Keywords: Antioxidants, circadian rhythms, cortisol, cocaine, hypoxia, melatonin, nitric oxide, oxidative stress, redox states.
Abstract: There is a vast literature dealing with various aspects of the circadian clock. This review provides examples of the multifaceted nature, of namely redox, oxidative stress, melatonin, antioxidants, nitric oxide, hypoxia, anesthetics, cortisol and cocaine. The redox and oxidative stress features reflect the involvement of electron transfer and radical species, which can exert either beneficial or deleterious effects. The harmful aspects can be countered by antioxidants. Melatonin is a brain hormone that is known to play a widespread role in the biochemistry of the circadian clock. Nitric oxide is widespread in the human body and plays a variety of roles. Hypoxia has been broadly discussed in relation to circadian rhythm, e.g., in high altitude flight. The anesthetic topic completes the list.
Export Options
About this article
Cite this article as:
Kovacic Peter and Somanathan Ratnasamy, Multifaceted Approach to Circadian Rhythm: Redox, Oxidative Stress, Melatonin, Antioxidants, Nitric Oxide, Hypoxia, Anesthetics, Cortisol and Cocaine, Current Chemical Biology 2013; 7 (3) . https://dx.doi.org/10.2174/22127968113079990002
DOI https://dx.doi.org/10.2174/22127968113079990002 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage
Cardiovascular & Hematological Agents in Medicinal Chemistry The Oxygen Therapy
Current Medicinal Chemistry Clinical Pharmacotherapy and Drug Development for Pulmonary Arterial Hypertension
Recent Patents on Cardiovascular Drug Discovery Abnormal Insulin Signaling: Early Detection of Silent Coronary Artery Disease-Erectile Dysfunction?
Current Pharmaceutical Design Management of Peyronie's Disease after Collagenase (Xiaflex:<sup>®</sup>)
Current Drug Targets Effect of GLP-1 Based Therapies on Diabetic Dyslipidemia
Current Diabetes Reviews Editorial [PCI and Stable Coronary Heart Disease - COURAGE to Change Our Minds?]
Current Vascular Pharmacology Venom Peptide Modulators of the Immune System
Inflammation & Allergy - Drug Targets (Discontinued) Patent Annotations
Recent Patents on Cardiovascular Drug Discovery Ultrasound Features of Polycystic Ovaries and Syndrome X: A Pilot Study
Vascular Disease Prevention (Discontinued) Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases
Mini-Reviews in Medicinal Chemistry Relationships of Birthweight and Postnatal Growth with Metabolic Risk Factors in Junior School Children in Korea
Current Hypertension Reviews Voltage-Gated Ion Channels, New Targets in Anti-Cancer Research
Recent Patents on Anti-Cancer Drug Discovery Neuroprotective Actions of Flavones and Flavonols: Mechanisms and Relationship to Flavonoid Structural Features
Central Nervous System Agents in Medicinal Chemistry Cardiomyopathy of Pregnancy
Current Women`s Health Reviews Mean Platelet Volume: A Link Between Thrombosis and Inflammation?
Current Pharmaceutical Design Beta-blockers in Intensive Care Medicine: Potential Benefit in Acute Brain Injury and Acute Respiratory Distress Syndrome
Recent Patents on Cardiovascular Drug Discovery Benefits of Olive Oil Phenolic Compounds in Disease Prevention
Endocrine, Metabolic & Immune Disorders - Drug Targets Associations between Alzheimer’s Disease and Blood Homocysteine, Vitamin B<sub>12</sub>, and Folate: A Case-Control Study
Current Alzheimer Research Rhinovirus-Associated Wheeze During Infancy and Asthma Development
Current Respiratory Medicine Reviews