Abstract
There is increased appreciation by the scientific community that dietary phytochemicals can be potential weapons in the fight against cancer. Emerging data has provided new insights into the molecular and cellular framework needed to establish novel mechanism-based strategies for cancer prevention by selective bioactive food components. The unique chemical composition of the pomegranate fruit, rich in antioxidant tannins and flavonoids has drawn the attention of many investigators. Polyphenol rich fractions derived from the pomegranate fruit have been studied for their potential chemopreventive and/or cancer therapeutic effects in several animal models. Although data from in vitro and in vivo studies look convincing, well designed clinical trials in humans are needed to ascertain whether pomegranate can become part of our armamentarium against cancer. This review summarizes the available literature on the effects of pomegranate against various cancers.
Keywords: Pomegranate extracts, cancer prevention.
Anti-Cancer Agents in Medicinal Chemistry
Title:Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities
Volume: 13 Issue: 8
Author(s): Deeba N. Syed, Jean-Christopher Chamcheu, Vaqar M. Adhami and Hasan Mukhtar
Affiliation:
Keywords: Pomegranate extracts, cancer prevention.
Abstract: There is increased appreciation by the scientific community that dietary phytochemicals can be potential weapons in the fight against cancer. Emerging data has provided new insights into the molecular and cellular framework needed to establish novel mechanism-based strategies for cancer prevention by selective bioactive food components. The unique chemical composition of the pomegranate fruit, rich in antioxidant tannins and flavonoids has drawn the attention of many investigators. Polyphenol rich fractions derived from the pomegranate fruit have been studied for their potential chemopreventive and/or cancer therapeutic effects in several animal models. Although data from in vitro and in vivo studies look convincing, well designed clinical trials in humans are needed to ascertain whether pomegranate can become part of our armamentarium against cancer. This review summarizes the available literature on the effects of pomegranate against various cancers.
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Syed N. Deeba, Chamcheu Jean-Christopher, Adhami M. Vaqar and Mukhtar Hasan, Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (8) . https://dx.doi.org/10.2174/1871520611313080003
DOI https://dx.doi.org/10.2174/1871520611313080003 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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