Methods: Balb/c mice were immunized with cardiac myosin peptides and complete Freund's adjuvant. CGA or vehicle (Cont) were administered orally from day 0 to day 21 (n=6 and 7, respectively). Mice were sacrificed on day 21.
Results: We found that the CGA significantly suppressed intercellular adhesion molecule-1 (ICAM-1) expression in the EAM hearts. The suppressed ICAM-1 tended to reduce myocardial fibrosis compared to control EAM hearts.
Conclusion: The findings suggest that the CGA influences inhibition of cell adhesion in myocarditis, the CGA treatment may have beneficial effects for progression of myocarditis.