Defense Mechanisms of the Respiratory System and Aerosol Production Systems
Paul Zarogoulidis, Kaid Darwiche, Lonny Yarmus, Dionysios Spyratos, Nevena Secen, Wolfgang Hohenforst-Schmidt, Nikolaos Katsikogiannis, Haidong Huang, Andreas Gschwendtner and Konstantinos Zarogoulidis
Pages 123-136 (14)
Aerosolized therapies have been used in everyday clinical practice for decades. Experimentation with different
delivery systems have led to the creation of aerosolized insulin, antibiotics, gene therapy and chemotherapy. Several of
these therapies are already clinically available while others are being investigated in active clinical trials. The main factors
affecting the efficiency and safety of the aerosolized therapies are the production of the aerosol, distribution/deposition of
the aerosol throughout the lung parenchyma, respiratory defense mechanisms and tissue/pharmaceutical molecule interactions.
Current methods of aerosol production and distribution will be presented along with an overview of the respiratory
defense mechanisms. In addition, methods of aerosol evaluation in conjunction with a future perspective of the potential
development of aerosol therapies will be presented.
Respiratory system, defense mechanisms, aerosol, dry powder, inhalers.
Pulmonary Department, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.