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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
VOLUME: 20
ISSUE: 14
DOI: 10.2174/13816128113196660661      Price:  $58









Small Molecule PET-Radiopharmaceuticals

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Author(s): Philip H. Elsinga and Rudi A.J.O. Dierckx
Pages 2268-2274 (7)
Abstract:
This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in 11C and 18F-radiochemistry are summarized. In addition an update of some new developments in regulatory aspects is supplied.
Keywords:
PET, small molecules, radiochemistry, preclinical evaluation, carbon-11, fluorine-18.
Affiliation:
University Medical Center Groningen, University of Groningen, the Netherlands and Ghent University, Belgium.