Abstract
Triamcinolone acetonide niosomes were prepared by thin film hydration technique using surfactants Brij 52, Span 20, cetrimide and cholesterol by 23 factorial design. Niosomes were evaluated for their morphology, vesicle size, in vitro drug release and skin permeation study using human skin. From the factorial design it was found that the cetrimide used in the formulation had greater effect on the entrapment efficiency, in vitro drug release and skin permeability and the particle size was found to be in the range of 50-80 nm. Clinical study was carried out using histamine wheal suppression test for the niosomal formulation and was compared with marketed product on healthy human volunteers with and without iontophoresis. It was found that niosomal formulation with iontophoresis at 15 min has more effect than at 60 min and 120 min when compared to the marketed product.
Keywords: Histamine wheal suppression, human volunteers, iontophoresis, niosomes, triamcinolone acetonide.
Pharmaceutical Nanotechnology
Title:Formulation and Clinical Evaluation of Triamcinolone Acetonide Niosomes: Effect of Iontophoresis on the Permeation Across Skin
Volume: 1 Issue: 4
Author(s): Veintramuthu Sankar, Elizabeth Babu, Karthik Siram, Shalini D. Penmetsa, Balakumar Kabila, Chakravarthi R. Srinavas and Reena Rai
Affiliation:
Keywords: Histamine wheal suppression, human volunteers, iontophoresis, niosomes, triamcinolone acetonide.
Abstract: Triamcinolone acetonide niosomes were prepared by thin film hydration technique using surfactants Brij 52, Span 20, cetrimide and cholesterol by 23 factorial design. Niosomes were evaluated for their morphology, vesicle size, in vitro drug release and skin permeation study using human skin. From the factorial design it was found that the cetrimide used in the formulation had greater effect on the entrapment efficiency, in vitro drug release and skin permeability and the particle size was found to be in the range of 50-80 nm. Clinical study was carried out using histamine wheal suppression test for the niosomal formulation and was compared with marketed product on healthy human volunteers with and without iontophoresis. It was found that niosomal formulation with iontophoresis at 15 min has more effect than at 60 min and 120 min when compared to the marketed product.
Export Options
About this article
Cite this article as:
Sankar Veintramuthu, Babu Elizabeth, Siram Karthik, Penmetsa D. Shalini, Kabila Balakumar, Srinavas R. Chakravarthi and Rai Reena, Formulation and Clinical Evaluation of Triamcinolone Acetonide Niosomes: Effect of Iontophoresis on the Permeation Across Skin, Pharmaceutical Nanotechnology 2013; 1 (4) . https://dx.doi.org/10.2174/22117385113016660008
DOI https://dx.doi.org/10.2174/22117385113016660008 |
Print ISSN 2211-7385 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-7393 |
Call for Papers in Thematic Issues
Polymeric nanocarriers in drug delivery
Polymeric nanocarriers play a crucial role in drug delivery due to their versatility, and unique properties for targeting and modifying drug release. Their ability to enhance therapeutic outcomes, reduce side effects, and enable the delivery of drugs in a more targeted and controlled manner made them popular in the last ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oxidative Stress and Endothelial Function: Therapeutic Interventions
Recent Patents on Cardiovascular Drug Discovery Effect of Microbial Transglutaminase on Protein Electrophoretic Pattern and Solubility of Wheat Flour and Hull-Less Barley Flour Blends
Current Nutrition & Food Science Molecular Design, Synthesis and Evaluation of 2,3-Diarylquinoxalines as Estrogen Receptor Ligands
Medicinal Chemistry (Neuro)Transmitter Systems in Circulating Immune Cells: A Target of Immunopharmacological Interventions?
Current Medicinal Chemistry The Glucocorticoid Receptor: Molecular Mechanism and New Therapeutic Opportunities
Current Drug Targets - Inflammation & Allergy GH-Inhibitory Activity of Novel Somatostatin Agonists: Potential Applications in Acromegaly
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Triterpenoid Saponins from Two Panax japonicus Varietals Used in Tujia Ethnomedicine
Current Traditional Medicine Human Leptin Regulation and Promise in Pharmacotherapy
Current Drug Targets Reactive Species, Cellular Repair and Risk Factors in the Onset of Type 2 Diabetes Mellitus: Review and Hypothesis
Current Diabetes Reviews Current Metabolomic Methodologies & their Application to Thermal Stress
Current Metabolomics Inhibitors of Angiogenesis in Cancer Therapy – Synthesis and Biological Activity
Current Medicinal Chemistry FGF21: The Center of a Transcriptional Nexus in Metabolic Regulation
Current Diabetes Reviews An Update on Management of Acute and Chronic Open Wounds: The Importance of Moist Environment in Optimal Wound Healing
Medicinal Chemistry Reviews - Online (Discontinued) Therapeutic Applications of Peptides against Zika Virus: A Review
Current Medicinal Chemistry α-Lipoic Acid and its Role on Female Reproduction
Current Protein & Peptide Science Mesalamine for Inflammatory Bowel Disease: Recent Reappraisals
Inflammation & Allergy - Drug Targets (Discontinued) A Comparative Study of Glucose and Fructose in the Development of Sarcoma 180 in Mice
Letters in Organic Chemistry Nutritional Assessment in the Critically Ill Child
Current Pediatric Reviews Clinical Pharmacology of EGFR/Met Inhibitors in Non-Small Cell Lung Cancer
Current Drug Targets Reliability of Blood Pressure Patterns Defined by a Single 24-Hour Ambulatory Blood Pressure Monitoring: The Case of the Dipping/Non Dipping and Isolated Clinic Hypertension
Current Hypertension Reviews