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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
VOLUME: 13
ISSUE: 2
DOI: 10.2174/18715273113126660140      Price:  $58









Genomic Linkage Between Alzheimer's Disease and Type 2 Diabetes

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Author(s): Taoufik Nedjadi, Absarul Haque, Qamre Alam, Siew H. Gan, Adeel G. Chaudhary, Adel M. Abuzenadah, Ghazi A. Damanhouri and Mohammad A. Kamal
Pages 203-212 (10)
Abstract:
Alzheimer’s disease (AD) is a major health concern that affects nearly every society worldwide. The disease is an irreversible, progressive and age-related neurodegenerative disorder. It is characterized by impaired cognitive function and the diffuse deposition of amyloid plaques and neurofibrillary tangles. The causes of AD and the underlying mechanisms that trigger the onset of the disease are still a matter of debate. Several epidemiological studies have shown that the development of AD is associated with type 2 diabetes mellitus (T2D). In this review, we provide evidence for the link between T2D and AD, highlighting the critical role of insulin in the pathogenesis of these diseases, and we provide information on the genes that might be involved in the interplay between these two disorders. New insight into the complex biology of AD is necessary for the early diagnosis of the disease, the development of novel drug therapies and the prevention of these health issues.
Keywords:
Alzheimer’s disease, type-2 diabetes, insulin, insulin resistance, genes.
Affiliation:
Fundamental and Applied Biology Group, King Fahd Medical Research Centre, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.