Alzheimer’s and Type 2 Diabetes Treatment via Common Enzyme Targeting
Nasimudeen R. Jabir, Mohammad A. Kamal, Adel Mohammad Abuzenadah, Siew Hua Gan, Mohammed Nabil Alama, Saleh S. Baeesa and Shams Tabrez
Pages 299-304 (6)
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two devastating diseases that are currently
incurable. Epidemiological, clinical and pathological evidence has confirmed the co-existence of these two disorders.
Moreover, there has been promising progress made in the identification of the pathological linkage between T2DM and
AD in the last decade. Hence, developing common treatment strategies for these diseases is important. Currently, enzyme
targeting is a potential strategy to cure many diseases. In this communication, we tried to summarize the single enzymetargeted
therapeutic approach for the treatment of AD and T2DM. This field of research continues to be active and
progressive in identifying many promising enzymes that are involved in both diseases. Based on this review article, we
also believe that enzyme inhibition is a promising and reliable strategy for the treatment of many incurable diseases. In the
future, we expect that the scientific community will be able to develop common enzyme inhibitors for the treatment of
both AD and T2DM.
Alzheimer’s disease, diabetes, enzymes, drug therapy, endocrine disorders.
King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.