Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to memory problems. It has been associated with type 2 diabetes mellitus at both the molecular and biochemical level. Pancreatic cells have molecular similarities to the brain at the transcriptomic and proteomic levels. Several genes have been reported to be responsible for both AD and diabetes. Currently, no proper treatment is available but various therapeutic approaches are utilized worldwide for the management of these disorders and may be nanoparticles and herbal treatment of Bacopa monnieri will make promise for the treatment of AD in future. The formation of amyloids in neurons and the formation of amylin in pancreatic cells are potential links between these two disorders, which can be silent killers.
Keywords: Neurodegenerative, type 2 diabetes mellitus, pancreatic cells, amyloid.
CNS & Neurological Disorders - Drug Targets
Title:Current View from Alzheimer Disease to Type 2 Diabetes Mellitus
Volume: 13 Issue: 3
Author(s): Mahmood Rasool, Arif Malik, Aamer M. Qazi, Ishfaq A. Sheikh, Abdul Manan, Sumaira Shaheen, Mahmood H. Qazi, Adeel G. Chaudhary, Adel M. Abuzenadah, Muhammad Asif, Mohammed H. Alqahtani, Zafar Iqbal, Munvar M. Shaik, Siew H. Gan and Mohammad A. Kamal
Affiliation:
Keywords: Neurodegenerative, type 2 diabetes mellitus, pancreatic cells, amyloid.
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to memory problems. It has been associated with type 2 diabetes mellitus at both the molecular and biochemical level. Pancreatic cells have molecular similarities to the brain at the transcriptomic and proteomic levels. Several genes have been reported to be responsible for both AD and diabetes. Currently, no proper treatment is available but various therapeutic approaches are utilized worldwide for the management of these disorders and may be nanoparticles and herbal treatment of Bacopa monnieri will make promise for the treatment of AD in future. The formation of amyloids in neurons and the formation of amylin in pancreatic cells are potential links between these two disorders, which can be silent killers.
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Rasool Mahmood, Malik Arif, Qazi M. Aamer, Sheikh A. Ishfaq, Manan Abdul, Shaheen Sumaira, Qazi H. Mahmood, Chaudhary G. Adeel, Abuzenadah M. Adel, Asif Muhammad, Alqahtani H. Mohammed, Iqbal Zafar, Shaik M. Munvar, Gan H. Siew and Kamal A. Mohammad, Current View from Alzheimer Disease to Type 2 Diabetes Mellitus, CNS & Neurological Disorders - Drug Targets 2014; 13 (3) . https://dx.doi.org/10.2174/18715273113126660167
DOI https://dx.doi.org/10.2174/18715273113126660167 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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