Login

Journal Image
Current Organocatalysis
ISSN (Print): 2213-3372
ISSN (Online): 2213-3380
VOLUME: 1
ISSUE: 1
DOI: 10.2174/22133372114016660004









L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems

img
Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar
Pages 51-58 (8)
Abstract:
Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.
Graphical Abstract:
Keywords:
2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.
Affiliation:
Department of Chemistry, University of Rajasthan, Jaipur, 302004, India.