The present review is focused on brief aspects of the synthesis of 4-quinoline carboxylic acids from isatins and its different derivatives. It also covers the literature on modification of original Pfitzinger reaction and its application for the synthesis of different bioactive molecules.
Different 4-quinoline carboxylic acids analogs synthesized by Pfitzinger reaction or modified Pfitzinger reaction have been tested for varied pharmacological activities. The review encompasses all literature reports of Pfitzinger reaction in the synthesis of different pharmacologically active molecules. This reaction with some modification has been widely used for the synthesis of a number of drugs or drug intermediates. The review also discusses the different chemistry aspects of Pfitzinger reaction.