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Central Nervous System Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Central Nervous System Agents)
ISSN (Print): 1871-5249
ISSN (Online): 1875-6166
VOLUME: 13
ISSUE: 2
DOI: 10.2174/18715249113136660016      Price:  $58









Semicarbazone Analogs as Anticonvulsant Agents: A Review

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Author(s): Mohamed Jawed Ahsan
Pages 148-158 (11)
Abstract:
Semicarbazones are synthesized by the condensation of semicarbazide and aldehyde/ketone. The literature survey revealed that semicarbazones had been emerged as compounds with diverse biological activities including anticonvulsant, antitubercular, anticancer, and antimicrobial activities. The anticonvulsant activity of semicarbazones is mainly attributed due to the presence of an aryl binding site with aryl/alkyl hydrophobic group, a hydrogen bonding domain and an electron donor group and they are suggested to act by inhibiting sodium ion (Na+) channel. Dimmock et al., reported an extensive series of semicarbazones and reported 4-(4-fluorophenoxy) benzaldehyde semicarbazone (C0102862, V102862) as lead molecule. In MES (oral) screening C0102862 showed protective index (PI > 315) more than carbamazepine (PI 101), phenytoin (PI > 21.6) and valproate (PI > 2.17). This review briefly describes the information available about semicarbazone analogs and their anticonvulsant activity.
Keywords:
Anticonvulsant Agents, Binding site theory, Na+ channel blocker, Pharmacophore model, Review, Semicarbazones.
Affiliation:
Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan 302 023, India.