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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives

Author(s): Wang Liju and Keyume Ablajan

Volume 11, Issue 2, 2014

Page: [310 - 316] Pages: 7

DOI: 10.2174/15701794113106660079

Price: $65

Abstract

Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.

Keywords: Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.

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