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Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
ISSN (Print): 1871-5206
ISSN (Online): 1875-5992
VOLUME: 14
ISSUE: 3
DOI: 10.2174/18715206113136660365      Price:  $58









Anticancer Activity of Ferrocenylthiosemicarbazones

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Author(s): Cortez-Maya Sandra, Klimova Elena, Flores-Alamo Marcos, Martínez-Klimova Elena, Ramírez-Ramírez Arturo, Ramírez Apan Teresa and Martínez-García Marcos
Pages 459-465 (7)
Abstract:
Aliphatic and aromatic ferrocenylthiosemicarbazones were synthesized. The characterization of the new ferrocenylthiosemicarbazones was done by IR, 1H-NMR and 13C-NMR spectroscopy, elemental analysis and X-ray diffraction studies. The biological activity of the obtained compounds was assessed in terms of anticancer activity. Their activity against U251 (human glyoblastoma), PC-3 (human prostatic adenocarcinoma), K562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma) and SKLU-1 (human lung adenocarcinoma) cell lines was studied and compared with cisplatin. All tested compounds showed good activity and the aryl-chloro substituted ferrocenylthiosemicarbazones showed the best anticancer activity.
Keywords:
Anti-cancer activity, ferrocene, thiosemicarbazones.
Affiliation:
Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, C.P. 04510, México D.F., México.