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Medicinal Chemistry
ISSN (Print): 1573-4064
ISSN (Online): 1875-6638
VOLUME: 10
ISSUE: 5
DOI: 10.2174/15734064113096660056      Price:  $58









An Efficient Ionic Liquid Mediated Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Piperidone Embedded α ,β-Unsaturated Ketones

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Author(s): Yalda Kia, Hasnah Osman, Raju Suresh Kumar, Vikneswaran Murugaiyah, Alireza Basiri, Kooi Yeong Khaw and Mohd. Mustaqim Rosli
Pages 512-520 (9)
Abstract:
A series of hitherto unreported piperidone embedded α,β-unsaturated ketones were synthesized efficiently in ionic solvent and evaluated for cholinesterase inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Most of the synthesized compounds displayed good enzyme inhibition; therein compounds 7i and 7f displayed significant activity against AChE with IC50 values of 1.47 and 1.74 µM, respectively. Compound 6g showed the highest BChE inhibitory potency with IC50 value of 3.41 µM, being 5 times more potent than galanthamine. Molecular modeling simulation was performed using AChE and BChE receptors extracted from crystal structure of human AChE and human BChE to determine the amino acid residues involved in the binding interaction of synthesized compounds and their relevant receptors.
Graphical Abstract:
Keywords:
AChE, BChE, Claisen-Schmidt Condensation, Chalcones, Molecular modeling.
Affiliation:
School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.