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Current Chemical Biology
ISSN (Print): 2212-7968
ISSN (Online): 1872-3136
VOLUME: 7
ISSUE: 2
DOI: 10.2174/2212796811307020010      Price:  $58









Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L.

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Author(s): Usama W. Hawas, Lamia T. Abou El-Kassem, Hanem M. Awad and Hanan A.A. Taie
Pages 188-195 (8)
Abstract:
Phytochemical investigation of the methanolic extract of Eryngium campestre L. aerial parts led to isolation of eleven known flavonol glycosides. Structures were elucidated by spectroscopic and chemical methods. The methanol extract of E. campestre and the isolated flavonols exhibited moderate to strong antioxidant activity in DPPH radical scavenging and reducing power assays. Eryngium campestre extract showed significant inhibition of the ß-amyloid Aß 42 (IC50 = 155.75±7.43 ng/ml) without significant reduction in total Aß (Aß 40 + Aß 42) levels in human H4 cell line, using sensitive sandwich enzyme linked immunosorbent assay (ELISA). The results showed no inhibition activity of the extract against COX-1 and COX-2 up to 400 ng/ml concentration.
Keywords:
Alzheimer's disease, β-amyloid peptide (Aβ), antioxidant, reducing power, flavonol glycosides, Eryngium campestre.
Affiliation:
Phytochemistry and Plant Systematic Department, National Research Centre, El-Bohooth Street, 12311, Dokki, Cairo, Egypt.