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Current Proteomics
ISSN (Print): 1570-1646
ISSN (Online): 1875-6247
VOLUME: 10
ISSUE: 3
DOI: 10.2174/1570164611310030003









Immunomics in Skin Cancer - Improvement in Diagnosis, Prognosis and Therapy Monitoring

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Author(s): Amanda Bulman, Monica Neagu and Carolina Constantin
Pages 202-217 (16)
Abstract:
This review will focus on the elements of the skin’s immune system, immune cells and/or non-immune cells that support immune mechanisms, molecules with immune origin and/or immune functions that are involved in skin carcinogenesis. All these immune elements are compulsory in the development of skin tumors and/or sustainability of the neoplastic process. In this light, recent data gathered in this review will acknowledge all immune elements that contribute to skin tumorigenesis; moreover, they can serve as immune biomarkers. These immune markers can contribute to the diagnostic improvement, prognosis forecast, therapy monitoring, and even personalized therapeutical approach in skin cancer. Immune processes that sustain tumorigenesis in non-melanoma and melanoma skin cancers are described in the framework of recent data.
Keywords:
Basal cell carcinoma, immunomics, lymphoma, melanoma, squamous cell carcinoma.
Affiliation:
Immunobiology Laboratory, “Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 050096, Bucharest, Romania.