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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
VOLUME: 17
ISSUE: 2
DOI: 10.2174/13862073113166660067









Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction

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Author(s): Abbas Rahmati, Zahra Khalesi and Tahmineh Kenarkoohi
Pages 132-140 (9)
Abstract:
A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.
Keywords:
Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.
Affiliation:
Department of Chemistry, University of Isfahan, P.O. Box 81746-73441, Isfahan, Iran.