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The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation
Editor(s): Kenneth Berendzen
Co-Editor(s): Joachim Kilian and Dierk Wanke
eISBN: 978-1-60805-492-3   ISBN: 978-1-60805-711-5   
Chapter PDF Price: $15

Gene Regulation By Epigenetic Mechanisms And Chromatin Structure

Author(s): Audrey Vincent and Isabelle Van Seuningen
Chapter DOI: 10.2174/9781608054923113010006
Page: 71-85 (15)

The term epigenetics defines heritable changes of gene expression that are not driven by the primary nucleotide sequence of a gene, but rather by the reorganisation of chromatin structures. In eukaryotes, chromatin allows the compaction of DNA into the nucleus via its basic structural subunit, the nucleosome, in which DNA is wrapped around histone octamers. This structure is timely and spatially remodeled to fit the needs of DNA replication and chromosome segregation during cell division processes, RNA transcription and DNA repair. In this chapter, we describe the two major mechanisms of epigenetic regulation: DNA methylation and covalent modifications of nucleosomal histone proteins, their crosstalk, and how their combinations switch on and off gene expression.
Chromatin, Epigenetics, DNA methylation, CpG, CpNpG, Imprinting, Histone Code, Histone variants, posttranslational modifications, Epigenomics, deacetylation, acetylation, ubiquitation.
Inserm, UMR837, Jean-Pierre Aubert Research Center, Team 5 "Mucins, epithelial differentiation and carcinogenesis", Lille, France.