Both cytokines and hormones induce changes in the post-translational modification of the protein, and these modifications are independent on the rate of synthesis of the AGP. This review will be subdivided in two parts. The first part will describe the structure of AGP (amino acid sequence and glycan pattern) and the several biological functions identified so far for this protein. The second part will be devoted to the posttranslational modifications of the glycan pattern of AGP due to pathological states, since one of the most interesting features of AGP is that its oligosaccharides microheterogeneity is profoundly affected by pathologic conditions and different glycoforms can appear in plasma during systemic inflammation or diseases.
The impact of different AGP glycoforms on both its transport and anti-inflammatory features and how the modifications of the glycan pattern can be utilized in clinical biochemistry will also be discussed.