Journal Image
Current HIV Research
ISSN (Print): 1570-162X
ISSN (Online): 1873-4251
DOI: 10.2174/1570162X113116660060      Price:  $58

Qualitative and Quantitative Variables that Affect the Potency of Fc- Mediated Effector Function In Vitro and In Vivo: Considerations for Passive Immunization Using Non-Neutralizing Antibodies

Author(s): George K Lewis
Pages 354-364 (11)
Passive immunization studies in non-human primates have established unequivocally that virus neutralization can prevent infection, providing the impetus for current intense efforts to identify immunogens that elicit broadly neutralizing antibodies in humans. Although Fc-mediated effector function may also contribute to protection by neutralizing antibodies, its role in protection by non-neutralizing antibodies is controversial. Here, I review the literature suggesting a role for Fc-mediated effector by non-neutralizing antibodies in protective immunity against HIV-1 with a primary focus on antibody mediated cellular cytotoxicity (ADCC) and related responses such as antibody-dependent cellular viral inhibition (ADCVI). Special emphasis is placed on qualitative and quantitative variables including antibody specificity and dose-response behavior in vitro and in vivo, which I propose as key variables in future passive immunization studies. Properly configured, these studies should clarify the role of Fc-mediated effector function by nonneutralizing antibodies in protection against HIV-1.
Antibody-dependent cell mediated cytotoxicity, antibody structure, antigen structure, Fc-mediated effector function.
Institute of Human Virology 725 West Lombard Street Baltimore MD 21201 USA