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Current Clinical Pharmacology
ISSN (Print): 1574-8847
ISSN (Online): 2212-3938
VOLUME: 9
ISSUE: 2
DOI: 10.2174/1574884708666131111201654      Price:  $58









CD26: A Multi-Purpose Pharmacological Target

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Author(s): Formica Vincenzo, Tesauro Manfredi, Cardillo Carmine and Roselli Mario
Pages 157-164 (8)
Abstract:
CD26 is a widely expressed transmembrane glycoprotein with peptidase activity in its extracellular domain and which regulates multiple biological processes.

It acts mainly as catabolic enzyme for a number of circulating proteins involved in common pathological conditions such as diabetes and cardiovascular disease and may represent a target to modulate bioavailability of crucial substrates.

The aim of the present review is to summarize data regarding CD26-based pharmacological interventions. Four main subtopics were identified:1) CD26 as the target of pharmacological inhibitors to increase bioavailability of glucagon-like petide-1 (GLP-1) and hence to enhance GLP-1 glucose-lowering activity in diabetic patients; 2) role of CD26 in the physiology and pathology of the cardiovascular system; 3) the adverse prognostic value of CD26 expression on cancer cells; 4) CD26 down-regulation on lymphocytes as a mechanism of TGF-beta immunomodulation.
Keywords:
CD26, colorectal cancer, dipeptidyl peptidase 4, glucagon-like petide-1, stromal cell-derived factor-1.
Affiliation:
Medical Oncology Unit, Internal Medicine Department, University Hospital 'Tor Vergata' , Viale Oxford, 81, 00133 Rome, Italy.