Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Recent Advances in the Synthesis of Antischistosomal Drugs and Agents

Author(s): Liang-xian Liu, Jiang Li-li, Chang Qiong and Fan Xiao-lin

Volume 17, Issue 5, 2017

Page: [467 - 484] Pages: 18

DOI: 10.2174/1389557513666131119204558

Price: $65

Abstract

Schistosomiasis is a notable neglected tropical disease caused by trematodes that infect mainly the intestines, bladder, and liver. Because of the unavailability of a schistosomiasis vaccine, control of the disease depends mainly on chemotherapy. Praziquantel (PZQ), which is active against all schistosome species (Among the five major species of human schistosomes−S. mansoni, S. haematobium, S. japonicum, S. intercalatum, and S. mekongi, S. mansoni is the most prevalent) as well as probably their hybrids and the recommended drug by the World Health Organization for schistosomiasis treatment at either the community or individual level, has become the exclusive drug because of its low cost and efficacy against the adult form of all schistosome species. In view of rapid re-infection following treatment and concern about the development of tolerance and/or resistance to praziquantel, there is an urgent need for research and development of novel drugs for the prevention and treatment of schistosomiasis. This comprehensive review shall attempt to briefly review the recent advances in the synthesis of antischistosomal drugs and agents in the literature from 1990s to now, particularly focusing on the context of potential development of antischistosomal agents. It shall be of interest for the pharmacologist.

Keywords: Antischistosomal drugs, chemotherapy, schistosomiasis, praziquantel.

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy