For six decades, natural products have taken a central role in the discovery of
new antimicrobial agents. The structural diversity of these compounds and its ability for
interacting specifically with biological target molecules has laid an ideal foundation in
the development of new drugs. The importance of fungus in TB treatment can be
observed in several aminoglycosides isolated from different Streptomyces species,
which are used as second line drug. Due to the fundamental importance of fungi in the
past and present of TB treatment, several research groups isolated and evaluated a
number of compounds from different fungal species against Mycobacterium
tuberculosis, which will be described in this chapter.
Tuberculosis; Mycobacterium tuberculosis; natural products; fungus;
semi-synthesis; synthesis; analogues; treatment; multi-drug-resistant tuberculosis
(MDR TB); extensive-drug-resistant tuberculosis (XDR TB); target; mechanism
of action; biological evaluation; drug development.
Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil.