Oxidative stress is an imbalance between cellular production of reactive oxygen species and the counteracting
antioxidant mechanisms. The brain with its high oxygen consumption and a lipid-rich environment is considered highly
susceptible to oxidative stress or redox imbalances. Therefore, the fact that oxidative stress is implicated in several mental
disorders including depression, anxiety disorders, schizophrenia and bipolar disorder, is not surprising. Although several
elegant studies have established a link between oxidative stress and psychiatric disorders, the causal relationship between
oxidative stress and psychiatric diseases is not fully determined. Another critical aspect that needs much attention and
effort is our understanding of the association between cellular oxidative stress and emotional stress. This review examines
some of the recent discoveries that link oxidative status with anxiety, depression, schizophrenia and bipolar disorder. A
discussion of published results and questions that currently exist in the field regarding a causal relationship between
oxidative and emotional stress is also provided.
Anxiety, depression, oxidative stress, psychological stress.
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, Room 557, University of Houston, Texas, TX77204, USA.