Oxidative stress caused by reactive species, including reactive oxygen species, reactive nitrogen species, and
unbound, adventitious metal ions (e.g., iron [Fe] and copper [Cu]), is an underlying cause of various neurodegenerative
diseases. These reactive species are an inevitable by-product of cellular respiration or other metabolic processes that may
cause the oxidation of lipids, nucleic acids, and proteins. Oxidative stress has recently been implicated in depression and
anxiety-related disorders. Furthermore, the manifestation of anxiety in numerous psychiatric disorders, such as generalized
anxiety disorder, depressive disorder, panic disorder, phobia, obsessive-compulsive disorder, and posttraumatic stress
disorder, highlights the importance of studying the underlying biology of these disorders to gain a better understanding of
the disease and to identify common biomarkers for these disorders. Most recently, the expression of glutathione reductase
1 and glyoxalase 1, which are genes involved in antioxidative metabolism, were reported to be correlated with anxietyrelated
phenotypes. This review focuses on direct and indirect evidence of the potential involvement of oxidative stress in
the genesis of anxiety and discusses different opinions that exist in this field. Antioxidant therapeutic strategies are also
discussed, highlighting the importance of oxidative stress in the etiology, incidence, progression, and prevention of
Antioxidant therapy, anxiety disorders, oxidative stress, toxicity.
Laboratorio de Neurociencia Comportamental, Departamento de Psicologia, Pontifícia Universidade Catolica do Rio de Janeiro, Rua Marques de Sao Vicente, 225, Rio de Janeiro, RJ, 22453-900 Brazil.