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Current Gene Therapy
ISSN (Print): 1566-5232
ISSN (Online): 1875-5631
VOLUME: 13
ISSUE: 6
DOI: 10.2174/1566523213666131125095046      Price:  $58









Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

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Author(s): William S.M. Wold and Karoly Toth
Pages 421-433 (13)
Abstract:
Adenovirus vectors are the most commonly employed vector for cancer gene therapy. They are also used for gene therapy and as vaccines to express foreign antigens. Adenovirus vectors can be replication-defective; certain essential viral genes are deleted and replaced by a cassette that expresses a foreign therapeutic gene. Such vectors are used for gene therapy, as vaccines, and for cancer therapy. Replication-competent (oncolytic) vectors are employed for cancer gene therapy. Oncolytic vectors are engineered to replicate preferentially in cancer cells and to destroy cancer cells through the natural process of lytic virus replication. Many clinical trials indicate that replication-defective and replication-competent adenovirus vectors are safe and have therapeutic activity.
Keywords:
Adenovirus, replication-defective, oncolytic, cancer gene therapy, vaccines, safe and well-tolerated.
Affiliation:
Saint Louis University School of Medicine, Department of Molecular Microbiology & Immunology, 1100 S. Grand Blvd., St. Louis, MO 63104. USA.