Abstract
Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.
Keywords: Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.
Letters in Drug Design & Discovery
Title:Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity
Volume: 11 Issue: 5
Author(s): Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonca Alves de Souza and Grace Gosmann
Affiliation:
Keywords: Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.
Abstract: Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.
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Dalla-Vechia Luciana, Kiekow Janine Cíntia, Leal Correa Ramos Ivana, Santos Regina Netto Dos Katia, Gnoatto Cristina Baggio Simone, Verli Hugo, Souza Octavio Mendonca Alves de Rodrigo and Gosmann Grace, Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity, Letters in Drug Design & Discovery 2014; 11 (5) . https://dx.doi.org/10.2174/1570180810666131125221032
DOI https://dx.doi.org/10.2174/1570180810666131125221032 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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