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Current Nanoscience
ISSN (Print): 1573-4137
ISSN (Online): 1875-6786
DOI: 10.2174/1573413709666131129000432      Price:  $58

A New Class of Biocompatible Tricalcium Phosphate/ Polypropylene Carbonate/ Polylactic Acid Nanocomposites with Controlled Flexibility and Biodegradability

Author(s): Ta-I Yang, Po-Liang Lin, Guang-Wei Chang, Yu-Chen Tseng, Zhe-Yang Yu, Charng-Bin Yang, Guo-Chung Dong and Hsu-Wei Fang
Pages 194-199 (6)
The goal of this research is to improve the mechanical and biological properties of widely used polylactic acid (PLA) in order to enhance the mechanical processability and bioactivity performance of the PLA-based medical implants. A polypropylene carbonate (PPC) polymer was utilized to control the bending strength of the PLA composites, leading to elastic PLA composites without any nontoxicity to osteoblast-like cells. Furthermore, a bioceramic material, tricalcium phosphate (β-TCP), was also introduced to further finetune the mechanical properties of the PLA composites. Experimental data revealed that the resulting elastic β-TCP/PPC/PLA nanocomposites exhibited elongation at break (%) of 1100% with tensile strength close to 1 MPa. The method developed in this study provides a simple strategy for fabricating biodegradable PLA based-materials with desired mechanical processability and malleability at room temperature.
Biocompatible, flexible, polylactic acid, polypropylene carbonate, tricalcium phosphate.
Department of Chemical Engineering, National Taipei University of Technology, Taipei 10608 Taiwan.