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Recent Patents on Biotechnology
ISSN (Print): 1872-2083
ISSN (Online): 2212-4012
Epub Full Text Article
DOI: 10.2174/1872208307666131202191925      Price:  $140

Patents in the Therapeutic Recombinant Protein Production Using Mammalian Cells

Author(s): Virgínia Picanço-Castro, Marcela Cristina Corrêa de Freitas, Aline de Sousa Bomfim and Elisa Maria de Sousa Russo
The industrial production of recombinant proteins requires, preferentially, the generation of stable cell lines expressing proteins in a quickly and reproducibly manner as well as with relative ease. Different methods are used to insert an exogenous DNA into the host cell and the choice of the producing cell is of paramount importance for the efficient production and quality of the recombinant protein. This review addresses the advances in recombinant proteins production in mammalian cell lines, according to the key patents in the last 20 years
Recombinant protein, mammalian expression system, patents in biopharmaceuticals
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil