Abstract
The nanotechnology and the use of nanoparticles are increasing each day. The number of experiments with nanoparticles is enormous and is corroborating the use in humans. However some points must be more defined before a final approval. In this study we analyzed nanoparticles of EDTMP under different conditions in rats and observed some characteristics that should be taken into account. Nanoparticles were injected either intraocular or in a jugular vein, and the data were compared. The behaviors of the samples were very different, which may have led to erroneous interpretation of nanoparticle data in previous studies by many authors. In all cases, the results of the biodistribution were quite different, which may lead to different conclusions. Analyzing the data, we conclude that the biodistribution test should be standardized, and the way that it is conducted may change the final results drastically.
Keywords: Animal model, biodistribution, cancer, nanotechnology, oncology.
Current Nanoscience
Title:Behavior of EDTMP (Ethylene-diaminetetramethylene-phosphonate)- Nanoparticles in Blood: Considerations on the Site of Injection
Volume: 10 Issue: 3
Author(s): Beatriz Ferreira de Carvalho Patricio, Osmar Flavio da Silveira Leite Neto, Marta de Souza Albernaz and Ralph Santos-Oliveira
Affiliation:
Keywords: Animal model, biodistribution, cancer, nanotechnology, oncology.
Abstract: The nanotechnology and the use of nanoparticles are increasing each day. The number of experiments with nanoparticles is enormous and is corroborating the use in humans. However some points must be more defined before a final approval. In this study we analyzed nanoparticles of EDTMP under different conditions in rats and observed some characteristics that should be taken into account. Nanoparticles were injected either intraocular or in a jugular vein, and the data were compared. The behaviors of the samples were very different, which may have led to erroneous interpretation of nanoparticle data in previous studies by many authors. In all cases, the results of the biodistribution were quite different, which may lead to different conclusions. Analyzing the data, we conclude that the biodistribution test should be standardized, and the way that it is conducted may change the final results drastically.
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Patricio Ferreira de Carvalho Beatriz, Neto Flavio da Silveira Leite Osmar, Albernaz de Souza Marta and Santos-Oliveira Ralph, Behavior of EDTMP (Ethylene-diaminetetramethylene-phosphonate)- Nanoparticles in Blood: Considerations on the Site of Injection, Current Nanoscience 2014; 10 (3) . https://dx.doi.org/10.2174/1573413709666131203231623
DOI https://dx.doi.org/10.2174/1573413709666131203231623 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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