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Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
VOLUME: 21
ISSUE: 22
DOI: 10.2174/0929867321666131212152637      Price:  $58









Delivery of Therapeutics and Molecules Using Self-Assembled Peptides

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Author(s): S. Sundar, Y. Chen and Y.W. Tong
Pages 2469-2479 (11)
Abstract:
The use of nanobiotechnology in the formulation of drug carriers has been gaining popularity in recent years. Peptide self-assembly technology is a particularly attractive option due to its simplicity and programmability. Selfassembling peptide amphiphiles are surfactant-like molecules that are capable of spontaneous organization into a variety of nanostructures. The structural and functional features of these nanostructures can be designed through alterations to the peptide sequence. With a keen understanding of the supramolecular principles governing the non-covalent interactions involved, drug loading strategies can be customised. Hydrophobic drugs can be hidden within the core via aromatic interactions while gene-based therapeutics can be complexed with a cationic region of lysine residues. This review article focuses on the application of self-assembling peptide amphiphiles to drug delivery in the area of anti-cancer therapeutics, protein- and peptide-based therapeutics and nucleic acid-based therapeutics. Specific examples are used to discuss the various systems available and emphasis is given to the encapsulation and release mechanism.
Keywords:
Anti-Cancer, drug delivery, growth factors, hormones, nanomedicine, nucleic acids, peptide amphiphiles, proteins, self-assembly, therapeutics.
Affiliation:
4 Engineering Drive 4, Singapore 117576.