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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
VOLUME: 13
ISSUE: 5
DOI: 10.2174/1871527312666131223114457      Price:  $58









Synaptic Activity-Regulated Wnt Signaling in Synaptic Plasticity, Glial Function and Chronic Pain

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Author(s): Shao-Jun Tang
Pages 737-744 (8)
Abstract:
Wnt signaling pathways play important roles in various developmental and oncogenic processes. In the nervous system, Wnt signaling regulates neuronal morphogenesis and synaptic differentiation. Disturbance of Wnt signaling is implicated in the pathogenesis of neurological diseases. Recent studies indicate that Wnt signaling in neurons is closely coupled to synaptic activation, and that the activity-regulated Wnt signaling is critical for the expression of synaptic plasticity and the formation of memory. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain.
Keywords:
Wnt, pain, synapse, glia, synaptic plasticity, neuroinflammation, N-methyl-D-aspartate, receptor, mammalian target of rapamycin, long-term potentiation, Human immunodeficiency virus-1.Wnt, pain, synapse, glia, synaptic plasticity, neuroinflammation, N-methyl-D-aspartate, receptor, mammalian target of rapamycin, long-term potentiation, Human immunodeficiency virus-1.
Affiliation:
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.